Sodium Hyaluronate Home > About Sodium Hyaluronate >

About Sodium Hyaluronate

Sodium Hyaluronate(normally call as Hyaluronic Acid) is the sodium salt of Hyaluronic Acid, it is a polymer of disaccharides, which are composed of D-glucuronic acid and D-N-acetylglucosamine, linked via alternating beta-1,4 and beta-1,3 glycosidic bonds. It was first found by Karl Meyer in 1934 and named hyaluronan.

Sodium hyaluronate can be obtained by extracting from cockscomb or through microorganism fermentation. The product in our company is all fermented products. The stain is Streptococcus equi subsp. Zooepidemicus, one of the naturally occurring lactic bacteria, and it does not involve any recombinant process. Commercial available hyaluronic acid is commonly its sodium salt form - Sodium hyaluronate.

Sodium Hyaluronate distributes widely in human body, such as in connective, epithelial, and neural tissues. Sodium Hyaluronate can be found in synovial fluid, hyaloids of eyes, skin and umbilical cords of mammals.
Sodium Hyaluronate plays an important role in human biologic activity. With the increase of age, content of Sodium Hyaluronate in the body will decrease. The decrease of Sodium Hyaluronate content in human body will weaken the water retaining ability of the skin, make the skin look coarse and wrinkle; lead to arthritis, arteriosclerosis, plus disorder and brain atrophy, and finally premature senility.
Sodium Hyaluronate is a safe agent for plastic surgery and many medical applications, as Sodium Hyaluronate is already found in human body, no need to worry about the immune responses or reject by our body.

Different Grades of Sodium Hyaluronate available as below:

Injection Grade Sodium Hyaluronate

Item No.	Intrinsic Viscosity m3/kg	Endotoxin	Certifications	Inquiry ($)
HA-EP1.8	1.6-2.2	≤0.05 IU/mg	US DMF, CEP, GMP, Japanese MF, Korean KDMF	Inquiry
HA-EP3.0	2.7-3.6	≤0.05 IU/mg	US DMF, CEP, GMP, Japanese MF, Korean KDMF	Inquiry
HA-EP2	0.2~4.0 (Sterile injectatable grade)	≤0.05 IU/mg	GMP, Japanese MF, DMF open part	Inquiry
HA-EP-N1	≤2.5 (Updated medical grade)	≤0.04 IU/mg	GMP, Japanese MF, DMF open part	Inquiry
HA-EP-N2	≥2.0 (Updated medical grade)	≤0.04 IU/mg	GMP, Japanese MF, DMF open part	Inquiry
Applications: Produce intra-articular and intra-ocular preparations, such as Ophthalmic Viscosurgical Device, intra-articular injections, intradermal injections for aesthetic correction, anti-adhesive products, etc.

Eye Drops Grade Sodium Hyaluronate
(Also called Pharmaceutical Grade Sodium Hyaluronate or Medical Grade Sodium Hyaluronate)

Item No.	Intrinsic Viscosity m3/kg	Endotoxin	Certifications	Inquiry ($)
HA-E3.0	2.7-3.6	≤0.5 IU/mg	US DMF, GMP, Japanese MF	Inquiry
HA-E2.0	1.2-2.8	≤0.5 IU/mg	US DMF, GMP, Japanese MF	Inquiry
HA-P-0.5	0.5-1.0	≤0.5 IU/mg	US DMF, GMP, Japanese MF	Inquiry
HA-EP1	0.2-4.0	≤0.5 IU/mg	GMP, Japanese MF, DMF open part	Inquiry
Applications: Produce oral preparations or parenteral preparations. It can be used in eye drops, drug carrier, contact lens solutions, topical preparations for wound or burn healing, medical lubricants, etc. but not including intra-articular and intra-ocular preparations.

Cosmetics Grade Sodium Hyaluronate

Item No.	Molecular weight	Inquiry ($)
HAC-H	≥1,800K Da	Inquiry
HAC-M	1,000K Da - 1,800K Da	Inquiry
HAC-L	10K Da - 1,000K Da	Inquiry
HAC-Oligo (mini HA)	<10K Da	Inquiry
HAC-N	200K Da - 600K Da	Inquiry
Applications: Skin care products: cream, emulsion, essence, lotion, gel, facial mask, etc. Beauty products: lipstick, eye shadow, foundation, etc. Cleansing products: facial cleanser, body wash, etc. Hair products: shampoo, hair conditioner, styling gel, hair restorer, etc.

Food Grade Sodium Hyaluronate

Item No.	Molecular weight	Inquiry ($)
HAF-H	≥1,800K Da	Inquiry
HAF-M	1,000K Da - 1,800K Da	Inquiry
HAF-L	10K Da - 1,000K Da	Inquiry
HAF-Oligo	<10K Da	Inquiry
HAF-N	200K Da - 600K Da	Inquiry
Applications: Used in food or health product as a dietary supplement.

Please note: Sodium Hyaluronate molecular weight range can be customized as requirements.

Injection Grade Sodium Hyaluronate

Introduce Injection Grade Hyaluronic Acid is mainly used for intra-articular and intra-ocular preparations. Injection Grade HA is widely used in plastic surgery, joint dysfunctions of human or animals (horse, dogs etc.), preventing postsurgical tissu...

Food Grade Sodium Hyaluronate

Introduce Sodium Hyaluronate has been reported to be absorbed and distributed to skin and joints after a single oral administration, which paves the way for Sodium Hyaluronate dietary supplements to be introduced and deliver on anti-aging and joint h...

Cosmetics Grade Sodium Hyaluronate

Introduce Hyaluronan as a function of raw material is widely used in cosmetics in following aspects: 1. Moisturizing and film-forming properties 2. Anti-Wrinkles 3. Anti-Irritation 4. Nutrition delivery 5. Free radical scavenging Feature 1. Reliable...

Medical Grade Sodium Hyaluronate

Introduce HA, due to its excellent viscoelastic behavior, high water retention capacity and lubrication, is widely used for Eye Drops. Eye Drops Grade Hyaluronic Acid can also produce oral preparations or parenteral preparations (not including intra-...